Kudzu Extract Reduces Alcohol Consumption by Heavy

McLean Hospital has licensed the production of kudzu extract (NPI-031) to Natural Pharmacia International (NPI), Inc. and they are marketing it as Alkontrol-Herbal®. All other authors declare that they have no actual or potential conflict of interest that could inappropriately influence, or be perceived to influence, this work. Kudzu root is available in lots of forms including capsules, liquid extracts, and powder.

kudzu extract for alcoholism

May reduce alcohol dependence

Along with easing uncomfortable symptoms, estrogen can help prevent bone loss after menopause. Kudzu root comes from a trailing vine that often grows over other plants. When it’s raw, kudzu root looks like other root tubers (think yams or ginger).

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with KUDZU

One possibility is through the different isoflavones, which are biologically active molecules that can affect physiology, contained within the kudzu extract. These data suggest that an extract of this leguminous plant may be a useful adjunct in reducing alcohol intake in a naturalistic setting. Lukas and Lee hold a patent for kudzu extract to treat alcohol abuse and dependence. McLean Hospital has licensed the production of kudzu extract (NPI-031) to Natural Pharmacia International (NPI), Inc. that markets it as Alkontrol-Herbal™. The lack of side effects could, with more research, make kudzu treatment an option for teens, pregnant women “and other vulnerable populations where a lack of medication toxicity is not only desirable but also necessary,” Lukas and colleagues write. Anti-inflammatory properties are attributed to decreased prostaglandin E2 and tumor necrosis factor-alpha release, both of which are involved in inflammatory processes (3).

kudzu extract for alcoholism

Alcoholism and Substance Abuse

According to traditional Chinese medicine, this plant has cooling properties that balance the heat and false energy created by alcohol. McLean Hospital has licensed the production of kudzu extract (NPI-031) to Natural Pharmacie International (NPI), Inc. and they are marketing it as Alkontrol-Herbal®. The major dependent variable was self-reported alcohol consumption as measured via the wrist actigraphy device. Using the continuous measure of alcohol consumption, drinking was quantified using a number of different variables as noted above. In addition, responses to the audible prompts multiple times a day were used to assess desire to consume alcohol.

  • David M. Penetar, senior author of the study and assistant Professor of Psychology in the Department of Psychiatry at McLean Hospital, said that kudzu has been around for centuries to treat alcohol intoxication, hangovers and other related problems in humans.
  • In response to these difficulties, Lukas and colleagues developed a concentrated kudzu extract with 25 percent isoflavones and developed the “natural laboratory” setting to test the extract’s effects.
  • The 14 participants, allowed to open only one drink at a time, were asked to drink from a mug that they set down on special tile topped table after each sip.
  • Seventeen men (21–33 years) who reported drinking 27.6 ± 6.5 drinks/week with a diagnosis of alcohol abuse/dependence took either kudzu extract (250 mg isoflavones, t.i.d.) or matched placebo on a daily basis.
  • Overconsumption of alcohol has significant negative effects on an individual’s health and contributes to an enormous economic impact on society as a whole.

Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. In theory, taking kudzu along with medication that might also harm the liver can increase kudzu extract for alcoholism the risk of liver damage. But kudzu isn’t as strong as the estrogen in birth control pills. Taking kudzu along with birth control pills might decrease the effectiveness of birth control pills. If you take birth control pills along with kudzu, use an additional form of birth control such as a condom.

kudzu extract for alcoholism

Overstreet et al.’s (1998) study provides cursory evidence that a taste aversion mechanism is not likely. Increases in 5-HIAL have been shown to be correlated with decreased alcohol consumption in hamsters (Keung et al., 1995). Kudzu’s alteration of alcohol consumption may be through direct effects at brain benzodiazepine receptors on the GABAA complex. This is the first demonstration that a single dose of kudzu extract quickly reduces alcohol consumption in a binge drinking paradigm.

A Standardized Kudzu Extract (NPI- Reduces Alcohol Consumption in Non Treatment-Seeking Male Heavy Drinkers

  • “Recently, preclinical studies with animals have shown reductions in alcohol consumption when treated with isoflavones contained in the kudzu root,” said Penetar.
  • This is precisely what was observed in the present study as kudzu’s effects were evident after a single dose within a few hours of administration.
  • It can be purchased with ease online and it won’t break the bank.
  • Drinking data were collected using a small wristwatch-like device (ActiWatch® Score, MiniMitter Co., OR) and daily diaries.

The volunteers were all friends, and so were likely to enjoy a relaxed evening’s drinking. Sub-group B was composed of 4 work colleagues, 2 men and 2 women. Kudzu, whose scientific name is Pueraria mirfica, is a vine used in Chinese medicine for a variety of health promoting purposes. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Tamoxifen (Nolvadex) is used to help treat and prevent these types of cancer.

  • We developed a standardized kudzu extract that preserved the ratio of the major isoflavones found in the raw root, except that the concentration of isoflavones was increased to 25%.
  • Daidzin (Fig. 1B) is also a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase (ALDH-2).
  • People often eat different parts of the plant raw, sautéed, deep-fried, baked, or jellied.
  • However, limited clinical studies exist to recommend use for any indication.

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kudzu extract for alcoholism

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